Lamotrigin bei unipolarer depression Stimmungsstabilisierer machen auch bei längerer Einnahme nicht abhängig. 1 Die Wirkung von Lamotrigin kann bei unipolarer Depression die Antidepressiva-Therapie verbessern. Wobei Fragen zu Dosierung und Sicherheit. 2 Lamotrigin gilt derzeit als eine der besten Optionen, die als Verstärkung eingesetzt werden können, wenn eine behandlungsresistente Depression. 3 Lamotrigin, ein Antiepileptikum, kann ein wirksames Medikament bei Depressionen, uni- oder bipolar sein. Bei der Bipolaren Störung wirkt es. 4 To review the available data behind the use of lamotrigine in unipolar depression and common comorbid conditions. A PubMed based literature review was conducted using keywords related to lamotrigine, depression, anxiety, post traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and personality disorders. 5 There have been a variety of studies using lamotrigine in the treatment of bipolar disorder and treatment-resistant unipolar depression. Fewer studies have looked at conditions which are often comorbid with affective illness such as anxiety disorders and personality disorders. 6 Lamotrigine can be used to treat the following partial seizures, primary generalized tonic-clonic seizures, bipolar I disorder maintenance and Lennox-Gastaut syndrome. Off-label uses include treating acute bipolar depression, fibromyalgia, schizophrenia, and unipolar depression. 7 Three patients abandoned the treatment with lamotrigine due to side-effects. Complaints were excessive somnolence, headache, dizziness, nausea and malaise. Data suggest that lamotrigine is a promising drug for treatment-refractory unipolar depression. Double-blind studies are necessary to confirm its use as an augmentation agent. 8 Lamotrigine is an important option in bipolar disorders. However, many clinicians also use it in patients with a (unipolar) depressive disorder who have not responded adequately to conventional antidepressants. Table — Randomized controlled trials of lamotrigine for MDD. 9 Dosage. During the first two weeks, patients typically take 25mg of lamotrigine every day. Then the dosage amount will increase to 50mg for week 3 to week 5. Maintenance dosage amounts are mg to mg a day. Always follow your doctor’s dosing schedule, as dosing may differ from patient to patient. lamotrigin depression absetzen 10